The role of the fallopian tube in ovarian cancer.

نویسندگان

  • Alicia A Tone
  • Shannon Salvador
  • Sarah J Finlayson
  • Anna V Tinker
  • Janice S Kwon
  • Cheng-Han Lee
  • Trevor Cohen
  • Tom Ehlen
  • Marette Lee
  • Mark S Carey
  • Mark Heywood
  • Judith Pike
  • Paul J Hoskins
  • Gavin C Stuart
  • Kenneth D Swenerton
  • David G Huntsman
  • C Blake Gilks
  • Dianne M Miller
  • Jessica N McAlpine
چکیده

High-grade serous carcinoma (HGSC) is the most common and lethal subtype of ovarian cancer. Research over the past decade has strongly suggested that "ovarian" HGSC arises in the epithelium of the distal fallopian tube, with serous tubal intraepithelial carcinomas (STICs) being detected in 5-10% of BRCA1/2 mutation carriers undergoing risk-reducing surgery and up to 60% of unselected women with pelvic HGSC. The natural history, clinical significance, and prevalence of STICs in the general population (ie, women without cancer and not at an increased genetic risk) are incompletely understood, but anecdotal evidence suggests that these lesions have the ability to shed cells with metastatic potential into the peritoneal cavity very early on. Removal of the fallopian tube (salpingectomy) in both the average and high-risk populations could therefore prevent HGSC, by eliminating the site of initiation and interrupting spread of potentially cancerous cells to the ovarian/peritoneal surfaces. Salpingectomy may also reduce the incidence of the 2 next most common subtypes, endometrioid and clear cell carcinoma, by blocking the passageway linking the lower genital tract to the peritoneal cavity that enables ascension of endometrium and factors that induce local inflammation. The implementation of salpingectomy therefore promises to significantly impact ovarian cancer incidence and outcomes.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fallopian Tube Carcinoma: A Case Report and Review of Litrature

Primary fallopian tube carcinoma is a rare tumor that histologically and clinically resembles epithelial ovarian cancer. Here we introduce a case of tubal carcinoma in a postmenopausal woman. The diagnosis of primary fallopian tube carcinoma is rarely considered preoperatively and is usually first appreciated by the pathologist. Because of low frequency of tubal carcinoma, there are few systemi...

متن کامل

بررسی شیوع پاتولوژی لوله‌های رحمی در بیماران مبتلا به نازایی اولیه و ثانویه، بر اساس یافته‌های هیستروسالپنگوگرافی Evaluation of the Prevalence of Fallopian Tube Abnormality in Primary and Secondary Infertility Based on Hysterosalpingography Findings

Abstract Background & Aim: Infertility is a relatively common problem, the prevalence of which is reported to be one in six couples. Among female factors, ovarian and tubal factors which are treatable are the most important ones. Laparascopy is the golden test for evaluation of fallopian tubes but because of its expensiveness, the necessity of general anesthesia and other problems, hystero...

متن کامل

The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin

High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, ...

متن کامل

Primary Fallopian Tube Cancer: An Unusual Case of Inguinal Lymphadenopathy

Background: Primary fallopian tube cancers (PFTCs) are rare gynecological malignancies by the prevalence of 0.3-1%. The PFTCs occur in individuals within the age range of 18-88 years, more specifically at the age range of 40-65 years with the mean age of 55 years. The PFTC usually is observed with the chronic inflammation of the fallopian tube, infertility, tuberculous salpingi...

متن کامل

Fallopian Tube Cancer — Diagnosis and Treatment

Fallopian tube tumors are rare with an incidence of 3.6 per one million. Fallopian tube carcinoma is of epithelial origin and share similar pathogenesis mechanisms with epithelial ovarian cancer. Early obstruction of the fallopian tube results in rapid onset of symptoms such as abdominal pain and distension and patients with fallopian tube carcinoma usually present at an early stage. Treatment ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical advances in hematology & oncology : H&O

دوره 10 5  شماره 

صفحات  -

تاریخ انتشار 2012